After a Diagnosis
of Cancer
Now that you have been given a diagnosis of cancer, the question of how
to treat your cancer lies in the hands of both you and your healthcare
team. For many types of cancer, there is no one “right” treatment.
You may have several options, each with benefits and risks attached.
You want to make sure your healthcare team uses the appropriate treatment(s)
for you. Finding out about your particular cancer is a great way to participate
knowledgeably in discussions about treatment. Your doctor, nurse and hospital
social workers are excellent sources of information. There are numerous
local and national organizations dedicated to helping patients and their
families cope with diagnosis, treatment and survivorship. Your local library
may also be a good source for information.
What is Cancer?
Cancer is a disease that occurs when the cells of the body begin to divide
and multiply in an uncontrolled way. Normally, cells have a defined lifecycle.
At the end of that cycle, they naturally pass away. This planned cell
death is called apoptosis. In cancer, this death is delayed or
does not happen for some cells. Without the “off switch,”
these cancerous cells continue to divide and multiply, which may cause
tumors. Given time, cancerous cells often develop the ability to distribute
themselves to other parts of the body. We call this spread of cells from
the original cancer site metastasis.
Cancer
can metastasize in three ways: through the lymphatic system,
through your blood vessels (the venous system), and by directly passing
from one organ to another. When cancer spreads through the lymphatic system,
it is carried by lymph fluid, a fluid that flows through lymph vessels
to most parts of your body. The role of the lymphatic system is to help
fight impurities and infections. The lymph vessels pass through lymph
nodes, which work like filters in the system. Cancer cells may be
caught and stay and grow in these nodes, or sometimes they will spread,
or metastasize, to other parts of your body. For example, breast cancer
may spread via the lymphatic system to the lymph nodes in the axilla (armpit).
If the cancer is not treated, it may spread onward to other lymph nodes
in other parts of the body.
The second way cancer may spread is through the venous system. For example,
if left untreated, a cancerous tumor in the breast may be shed cancerous
cells into the veins of the breast. The cells then may be carried by the
blood vessels through the heart and then lodge in the left lung, causing
a secondary cancer to grow there. Cancer may also spread by direct extension
from one organ to another. In this breast cancer example a primary cancer
of the breast may spread directly to the chest wall behind it.
Why Does Cancer Make People Sick?
Cancer makes people sick because the cancerous cells take the place of
healthy cells. Cancerous cells use up the energy and oxygen your normal
cells need to keep going. This stealing process is one reason people with
cancer may be very tired or fatigued and lose weight. If a tumor becomes
large enough, it may press on important nerves, causing pain. A tumor
may take over the cells of a healthy organ, slowing or preventing the
organ’s normal function. This is why someone with lung cancer may
find it hard to breathe.
What Causes Cancer to Happen?
Cells stop their normal life cycle process because of changes in their
genetic makeup. Sometimes we inherit genes from our parents that are not
perfect and make us more likely to get cancer. Environmental factors can
damage cells; for example, getting too many sunburns and suntans may damage
skin cells. Not everyone with inherited flaws or exposure to damaging
environments gets cancer. It requires a sequence of changes in multiple
genes to start a cancer. This is why we see some heavy smokers live until
they are very old and never get cancer, and others develop lung cancer
very young.
Genes that cause cancer when they have changed or mutated are
called oncogenes. Another way cancer develops is when tumor
suppressor genes, the natural “brakes” we have to prevent
cancer, develop mutations. Every type of cancer has a unique set of genetic
mutations associated with it, but some changes are seen in a number of
cancers, such as the p53 gene mutation. No one mutation has yet
been identified that is associated with every cancer. |